Equipa envolvida
Equipa de investigação e apoiantes
Debbie é Professor - Principal Investigator da Erasmus MC, Cell Biology
She managed to grow human brain organoids that allow us to investigate how structures of particular brain regions are formed, similar to what happens in the very early stages of a human embryo.
Sylvia é Clinical Supervisor and Trainer da Zodiak-Prinsenstichting, MD PhD a expertise centrum Cornelia de Lange syndroom, Medical Director a Vereniging Cornelia de Lange syndroom, (MD) Physician for ID, SIB & CdLS a International Scientific Advisory Council (SAC)
She will manage the interactions with the patients/caretakers and the CdLS family organization and help to collect tissue samples.
Mehrnaz é Head iPS core facility da Erasmus MC, iPS core facility
Mehrnaz Ghazvini and her team from the iPS core facility will derive induced pluripotent stem cells from patient samples, which we need to grow the organoids.
Kerstin é Lid van de SAC da Vereniging Cornelia de Lange syndroom, Molecular Genetics Research a International Scientific Advisory Council (SAC), Professor - Principal Investigator a Erasmus MC, Cell Biology
Together, we want to understand how mutations in the NIPBL gene affect the proper development of the human brain. An important aspect is to find out how brain development is affected when only a few cells have the mutation (mosaicism).
Kerstin Wendt and her PhD student Amber Hof will study which genes are affected.
Amber completed her master's degree in Molecular Neuroscience at the University of Amsterdam, where she gained extensive experience researching nerve stem cells in the adult brain.
Debbie van den Berg, her PhD student Marieke Alzeer supported by Anne Korporaal will use imaging to study the behavior of the cells.
Marieke completed the master's degree in Neuroscience and Cognition at Utrecht University; during her master's, she worked with 3-dimensional organoids to mimic brain development.
Debbie van den Berg, her PhD student Marieke Alzeer supported by Anne Korporaal will use imaging to study the behavior of the cells.
