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Precocious Puberty


Domanda

My 8 year old daughter was diagnosed with precocious puberty. Her physician is recommending Lupron depot. Has this been effective with other girls with CdLS?

Risposta dei nostri esperti

Precocious puberty occurs typically before age 8 in girls. Regarding the treatment, Lupron depot is the only depot treatment (long-acting, pulsatile) used in the US for precocious puberty when the cause is related to the activation of hormones from the brain (hypothalamus/pituitary gland). The treatment prevents the growth spurt to improve final adult height, and also somewhat treats the early puberty symptoms. If your daughter is followed by a pediatric endocrinologist, then I think everything sounds appropriate. I am not aware of this treatment previously in CdLS

TK 7-13-10

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Autonomic nervous system

R47
Seizures in individuals with CdLS should be treated using the general management schemes.
R48
An MRI of the brain should be considered only if the individual with CdLS shows neurological signs other than microcephaly (smaller than normal head).

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Health difficulties in CdLS...
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