Fig. 4: Cornelia de Lange Syndrome (CdLS) is a cohesinopathy
Fig. 4 | Cornelia de Lange Syndrome (CdLS) is a cohesinopathy(changes in genes associated with CdLS affect the cohesin complex). CdLS is caused by genetic variants that affect regulators of the cohesin complex. The structural components form a ring and cohesin subunits (such as STAG 1) attach to the ring and form part of the core complex.