Do Cognitive and Behavioural Characteristics Change with Age in CdLS?

Research has suggested that behavioural, emotional and cognitive characteristics in CdLS can change with age (²,¹³⁷,¹³⁹,¹⁴⁸,¹⁷²). Findings from one study suggest an association between age and a higher number of behavioural difficulties in individuals with CdLS (¹³⁷). In this study, older age was specifically associated with lower levels of interest and pleasure, and greater insistence on sameness (¹⁴⁸). This suggests older individuals with CdLS display more difficulties.

Research has also suggested that individuals with CdLS can experience increasing difficulties in the frequency and severity of many behavioural characteristics with age. These changes are reported to affect verbal working memory, ASD symptoms, anxiety, low mood, self-injurious behaviour and impulsivity (²,⁹⁰,¹⁰⁹,¹³⁹,⁵⁴,¹⁶⁶,¹⁷²,¹⁷⁴). Aggression, hyperactivity and sleep difficulties in CdLS may not become more frequent or severe with age.

Challenging behaviour may begin during adolescence and early adulthood (¹⁰⁹,¹⁶⁷,¹⁷²). Individuals with CdLS benefit from support during these transitional periods, which can help to reduce mental health issues and challenging behaviour (R65). Support should include using a person-centred approach, gradually introducing changes and considering the individual’s social environment.

Antonie D. Kline, Joanna F. Moss, […]Raoul C. Hennekam

_{Adapted from: Kline, A. D., Moss, J. F., Selicorni, A., Bisgaard, A., Deardorff, M. A., Gillett, P. M., Ishman, S. L., Kerr, L. M., Levin, A. V., Mulder, P. A., Ramos, F. J., Wierzba, J., Ajmone, P.F., Axtell, D., Blagowidow, N., Cereda, A., Costantino, A., Cormier-Daire, V., FitzPatrick, D., Grados, M., Groves, L., Guthrie, W., Huisman, S., Kaiser, F. J., Koekkoek, G., Levis, M., Mariani, M., McCleery, J. P., Menke, L. A., Metrena, A., O’Connor, J., Oliver, C., Pie, J., Piening, S., Potter, C. J., Quaglio, A. L., Redeker, E., Richman, D., Rigamonti, C., Shi, A., Tümer, Z., Van Balkom, I. D. C. and Hennekam, R. C. (2018).}

Source:

Diagnosis and management in Cornelia de Lange Syndrome: First international consensus statement. Nature Reviews Genetics, 19, 649-666, published on 11 Juli 2018

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Zuletzt geändert von Gerritjan Koekkoek am 2022/09/29 16:10

Erstellt von Gerritjan Koekkoek am 2019/03/27 15:09